Nexonco Mcp
An advanced MCP Server for accessing and analyzing clinical evidence data, with flexible search options to support precision medicine and oncology research.
what is Nexonco Mcp?
Nexonco Mcp is an advanced MCP Server designed for accessing and analyzing clinical evidence data, specifically from the CIViC database, to support precision medicine and oncology research.
how to use Nexonco Mcp?
To use Nexonco Mcp, set up the server by following the provided setup guides, and utilize the search_clinical_evidence tool to query clinical evidence data based on various filters.
key features of Nexonco Mcp?
- Fast and flexible search options across variants, diseases, drugs, and phenotypes.
- Detailed output reports with summary statistics and evidence entries.
- Integration with Claude Desktop for enhanced functionality.
use cases of Nexonco Mcp?
- Researchers can find predictive evidence for cancer therapies.
- Clinicians can explore studies related to specific diseases and treatments.
- Oncologists can analyze clinical evidence to inform treatment decisions.
FAQ from Nexonco Mcp?
- What is the purpose of Nexonco Mcp?
It is designed to facilitate access to clinical evidence for precision oncology research.
- Is there a cost to use Nexonco Mcp?
No, Nexonco Mcp is free to use for research purposes.
- Can I use Nexonco Mcp for medical advice?
No, it is intended for research purposes only and not as a substitute for professional medical advice.
Demo
https://github.com/user-attachments/assets/02129685-5ba5-4b90-89e7-9d4a39986210
Watch full video here:
Setup
Prerequisites
- uv or Docker
- Claude Desktop (for MCP integration)
Setup Guides
For detailed setup instructions, refer to the following documentation:
-
NANDA Host Setup
Seedocs/nanda-server-setup.mdfor backend configuration and local registration of the NANDA Server. -
Claude Desktop Setup
Seedocs/claude-desktop-setup.mdfor guidance on configuring the local development environment and MCP integration.
These guides include all required steps, environment configurations, and usage notes to get up and running.
Tool List
search_clinical_evidence: A MCP tool for querying clinical evidence data that returns formatted reports.
Input Schema
The tool accepts the following optional parameters:
disease_name(str): Filter by disease (e.g., "Lung Non-small Cell Carcinoma").therapy_name(str): Filter by therapy or drug (e.g., "Cetuximab").molecular_profile_name(str): Filter by gene or variant (e.g., "EGFR L858R").phenotype_name(str): Filter by phenotype (e.g., "Chest Pain").evidence_type(str): Filter by evidence type (e.g., "PREDICTIVE", "DIAGNOSTIC").evidence_direction(str): Filter by evidence direction (e.g., "SUPPORTS").filter_strong_evidence(bool): IfTrue, only includes evidence with a rating > 3 (max 5).
Output
The tool returns a formatted string with four sections:
- Summary Statistics:
- Total evidence items
- Average evidence rating
- Top 3 diseases, genes, variants, therapies, and phenotypes (with counts)
- Top 10 Evidence Entries:
- Lists the highest-rated evidence items with details like disease, phenotype, gene/variant, therapy, description, type, direction, and rating.
- Sources & Citations:
- Citations and URLs for the sources of the top 10 evidence entries.
- Disclaimer:
- A note stating the tool is for research purposes only, not medical advice.
Sample Usage
- "Find predictive evidence for colorectal cancer therapies involving KRAS mutations."
- "Are there studies on Imatinib for leukemia?"
- "What therapies are linked to pancreatic cancer evidence?"
Acknowledgements
- Model Context Protocol
- NANDA: The Internet of AI Agents
- CIViC - Clinical Interpretation of Variants in Cancer
License
This project is licensed under the MIT License - see the LICENSE file for details.
Disclaimer
⚠️ This tool is intended exclusively for research purposes. It is not a substitute for professional medical advice, diagnosis, or treatment.
Contributors
- Obada Qasem (@obadaqasem), Nexgene AI
- Kutsal Ozkurt (@Goodsea), Nexgene AI
